Free Book Online
Book New Strategies in Quantitative Structure-Activity Relationships: Applications to Adenosine Receptor Ligands

Pdf

New Strategies in Quantitative Structure-Activity Relationships: Applications to Adenosine Receptor Ligands

2.2 (2381)

Log in to rate this item

    Available in PDF - DJVU Format | New Strategies in Quantitative Structure-Activity Relationships: Applications to Adenosine Receptor Ligands.pdf | Language: ENGLISH
    Alice Borghini (Author)

    Book details


Quantitative Structure-Activity Relationships (QSAR) is a technique used to establish correlations between chemical structures and a given target property, such as the affinity at a given receptor. QSAR represents an important tool in drug design, allowing early prediction of the biological activity of newly designed molecules. In this work, QSAR methods were applied to ligands for the adenosine receptors, which possess many therapeutic potentials. Two different approaches were attempted: on one hand the rigorous observation of QSAR guidelines provided by the Organisation for Economic Co-operation and Development (OECD) in each step of model development, on the other hand an innovative and more dynamic method. In both cases, attention was focused on the validation of the obtained models, especially concerning their goodness-of-fit, robustness, predictive ability and applicability domain. Due to the wide range of possible applications of QSAR methods, this book is addressed not only to QSAR modelers working in the medicinal chemistry field, but to all modelers who desire to predict biological, as well as toxicological, physico-chemical and many other properties.
3.3 (12626)
  • Pdf

*An electronic version of a printed book that can be read on a computer or handheld device designed specifically for this purpose.

Formats for this Ebook

PDF
Required Software Any PDF Reader, Apple Preview
Supported Devices Windows PC/PocketPC, Mac OS, Linux OS, Apple iPhone/iPod Touch.
# of Devices Unlimited
Flowing Text / Pages Pages
Printable? Yes

Book details

  • PDF | 148 pages
  • Alice Borghini (Author)
  • VDM Verlag (1 May 2009)
  • English
  • 9
  • Health, Family Lifestyle

Read online or download a free book: New Strategies in Quantitative Structure-Activity Relationships: Applications to Adenosine Receptor Ligands

 

Review Text


Name:
Email*:
The message text*: